BizTalk Adapter 2.0 for mySAP Business Suite: Error in Check Transaction Failed to load the runtime

This weekend after installing .NET Framework 4.0 in a BizTalk Server 2006 R2 environment, the BizTalk Adapter 2.0 for mySAP Business Suite started to throw the following error when he tried to receive data from the SAP system.

“Event Source: BizTalk Adapter v2.0 for mySAP Business Suite
Description: Error in Check Transaction: Failed to load the runtime.
(Exception from HRESULT: 0x80131700)”

BizTalk Adapter mySAP Business Suite Transaction Failed to load the runtime


This issue occurs after installing .NET Framework 4.0. The registration of the assembly used by mySAP Business Suite does not specify the correct version of the .NET Framework. When .NET Framework 4.0 is installed, the assembly will try to use the newer framework and then raise this error.


You need to manually reregister the sapreceiver.dll (this DLL is usually in this folder: “C:\Program Files\Microsoft BizTalk Adapter v2.0 for mySAP Business Suite\”). To accomplish that you need to:

  • Execute cmd (Start → cmd)
  • Type “cd C:\Windows\Microsoft.NET\Framework\v1.1.4322”
  • And execute the following command to fixed the problem:
    • regasm.exe “C:\Program Files\Microsoft BizTalk Adapter v2.0 for mySAP Business Suite\sapreceiver.dll”

Note: When you install .NET Framework 4.0 in older versions of BizTalk Server like BizTalk Server 2006 or 2006 R2, normally, you will also have problems with the Enterprise Single Sign-On Service for the exact same reasons and the solution is also to manually reregister the DLL but this time the SSOSQL.dll. To find more about this error check: Fixing BizTalk ENTSSO – Could not create SSOSQL. To fix the problem, reinstall SSO or try ‘regasm SSOSQL.dll’ from a Visual Studio command prompt.

Author: Sandro Pereira

Sandro Pereira lives in Portugal and works as a consultant at DevScope. In the past years, he has been working on implementing Integration scenarios both on-premises and cloud for various clients, each with different scenarios from a technical point of view, size, and criticality, using Microsoft Azure, Microsoft BizTalk Server and different technologies like AS2, EDI, RosettaNet, SAP, TIBCO etc. He is a regular blogger, international speaker, and technical reviewer of several BizTalk books all focused on Integration. He is also the author of the book “BizTalk Mapping Patterns & Best Practices”. He has been awarded MVP since 2011 for his contributions to the integration community.

1 thought on “BizTalk Adapter 2.0 for mySAP Business Suite: Error in Check Transaction Failed to load the runtime”

  1. Hi Sandro, what’s the best way to have a SAP instance that I can test with BizTalk. I need to do a POC and I have MSDN subscription so I have BizTalk.. but from where do I get hold SAP. Is there some kind of a free or trial version available. Any pointers will be helpful.

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